Interplay Between the Persistent Random Walk and the Contact Inhibition of Locomotion Leads to Collective Cell Behaviors.

ABSTRACT: Cell migration plays an important role in physiology and pathophysiology. It was observed in the experiments that cells, such as fibroblast, leukocytes, and cancer cells, exhibit a wide variety of migratory behaviors, such as persistent random walk, contact inhibition of locomotion, and ordered behaviors. To identify biophysical mechanisms for these cellular behaviors, we developed a rigorous computational model of cell migration on a two-dimensional non-deformable substrate. Cells in the model undergo motion driven by mechanical interactions between cellular protrusions and the substrate via the balance of tensile forces. Properties of dynamic formation of lamellipodia induced the persistent random walk behavior of a migrating cell. When multiple cells are included in the simulation, the

SUBMITTER: Hassan AR 

PROVIDER: S-EPMC6679770 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature