Association between non-invasive liver fibrosis scores and occurrence of health adverse outcomes in older people.

ABSTRACT:

Background

The relation between liver fibrosis scores and health outcomes in older people has been barely investigated. We aimed to evaluate the association of four liver fibrosis scores (fibrosis-4 -FIB-4-, NAFLD fibrosis score -NFS-, BARD and aspartate aminotransferase/alanine aminotransferase ratio -AST/ALT-) with mortality and incident disability at 6 years in an older population.

Methods

We studied 962 individuals aged ≥65 (mean age 74.4; female 55.5%) with a mean follow-up of 95.7 months, enrolled in the InCHIANTI study. The relationship between liver fibrosis scores and mortality and disability was assessed through Cox and log-binomial regressions.

Results

NFS and FIB-4 were associated with higher overall (aHR ranging 1.38-1.78 for intermediate risk of fibrosis

SUBMITTER: De Vincentis A 

PROVIDER: S-EPMC6679815 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature