Airborne mammary carcinogens and breast cancer risk in the Sister Study.

ABSTRACT:

Introduction

Potentially carcinogenic hazardous air pollutants (air toxics) have been inconsistently associated with breast cancer. Whether metabolic factors modify these associations is unknown. We studied 29 non-metallic air toxics classified as mammary gland carcinogens in animal studies in relation to breast cancer risk.

Methods

Participants included 49,718 women from the Sister Study. Census tract air toxic concentration estimates from the 2005 National Air Toxics Assessment were linked to enrollment residential addresses. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for individual air toxics were estimated using Cox regression. Body mass index (BMI) was considered a potential modifier. Relevant mixtures were identified using classification trees.

SUBMITTER: Niehoff NM 

PROVIDER: S-EPMC6679994 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature