Ontology highlight
ABSTRACT:
SUBMITTER: Lundh M
PROVIDER: S-EPMC6680131 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Lundh Morten M Petersen Patricia Ss PS Isidor Marie S MS Kazoka-Sørensen Dolly Nm DN Plucińska Kaja K Shamsi Farnaz F Ørskov Cathrine C Tozzi Marco M Brown Erin L EL Andersen Emil E Ma Tao T Müller Ulrich U Barrès Romain R Kristiansen Viggo B VB Gerhart-Hines Zachary Z Tseng Yu-Hua YH Emanuelli Brice B
EMBO reports 20190702 8
Insulin orchestrates metabolic homeostasis through a complex signaling network for which the precise mechanisms controlling its fine-tuning are not completely understood. Here, we report that Afadin, a scaffold protein, is phosphorylated on S1795 (S1718 in humans) in response to insulin in adipocytes, and this phosphorylation is impaired with obesity and insulin resistance. In turn, loss of Afadin enhances the response to insulin in adipose tissues via upregulation of the insulin receptor protei ...[more]