Identifying Novel Sepsis Subphenotypes Using Temperature Trajectories.

ABSTRACT: Rationale: Sepsis is a heterogeneous syndrome, and identifying clinically relevant subphenotypes is essential.Objectives: To identify novel subphenotypes in hospitalized patients with infection using longitudinal temperature trajectories.Methods: In the model development cohort, inpatient admissions meeting criteria for infection in the emergency department and receiving antibiotics within 24 hours of presentation were included. Temperature measurements within the first 72 hours were compared between survivors and nonsurvivors. Group-based trajectory modeling was performed to identify temperature trajectory groups, and patient characteristics and outcomes were compared between the groups. The model was then externally validated at a second hospital using the same inclu

SUBMITTER: Bhavani SV 

PROVIDER: S-EPMC6680307 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature