Thread as a Low-Cost Material for Microfluidic Assays on Intact Tumor Slices.

ABSTRACT: In this paper we describe the use of thread as a low-cost material for a microfluidic chemosensitivity assay that uses intact tumor tissue ex vivo. Today, the need for new and effective cancer treatments is greater than ever, but unfortunately, the cost of developing new chemotherapy drugs has never been higher. Implementation of low-cost microfluidic techniques into drug screening devices could potentially mitigate some of the immense cost of drug development. Thread is an ideal material for use in drug screening as it is inexpensive, widely available, and can transport liquid without external pumping hardware, i.e., via capillary action. We have developed an inexpensive microfluidic delivery prototype that uses silk threads to selectively deliver fluids onto subregions of living xenograf

SUBMITTER: Rumaner M 

PROVIDER: S-EPMC6680473 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature