The Host-Microbe Interplay in Human Papillomavirus-Induced Carcinogenesis.

ABSTRACT: Every year nearly half a million new cases of cervix cancer are diagnosed worldwide, making this malignancy the fourth commonest cancer in women. In 2018, more than 270,000 women died of cervix cancer globally with 85% of them being from developing countries. The majority of these cancers are caused by the infection with carcinogenic strains of human papillomavirus (HPV), which is also causally implicated in the development of other malignancies, including cancer of the anus, penis cancer and head and neck cancer. HPV is by far the most common sexually transmitted infection worldwide, however, most infected people do not develop cancer and do not even have a persistent infection. The development of highly effective HPV vaccines against most common high-risk HPV strains is a great medical a

SUBMITTER: Wakabayashi R 

PROVIDER: S-EPMC6680694 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature