Multi-Target β-Protease Inhibitors from Andrographis paniculata: In Silico and In Vitro Studies.

ABSTRACT: Natural products derived from plants play a vital role in the discovery of new drug candidates, and these are used for novel therapeutic drug development. Andrographis paniculata and Spilanthes paniculata are used extensively as medicinal herbs for the treatment of various ailments, and are reported to have neuroprotective properties. β-amyloid is a microscopic brain protein whose significant aggregation is detected in mild cognitive impairment and Alzheimer's disease (AD) brains. The accumulation of β-amyloid disrupts cell communication and triggers inflammation by activating immune cells, leading to neuronal cell death and cognitive disabilities. The proteases acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta secretase-1 (BACE-1) have been reported to be correlated with

SUBMITTER: Panche AN 

PROVIDER: S-EPMC6681301 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature