Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging.

ABSTRACT: Cerebral blood flow is an important parameter in many diseases and functional studies that can be accurately measured in humans using arterial spin labelling (ASL) MRI. However, although rat models are frequently used for preclinical studies of both human disease and brain function, rat CBF measurements show poor consistency between studies. This lack of reproducibility is due, partly, to the smaller size and differing head geometry of rats compared to humans, as well as the differing analysis methodologies employed and higher field strengths used for preclinical MRI. To address these issues, we have implemented, optimised and validated a multiphase pseudo-continuous ASL technique, which overcomes many of the limitations of rat CBF measurement. Three rat strains (Wistar, Sprague Dawley and

SUBMITTER: Larkin JR 

PROVIDER: S-EPMC6681434 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature