A closer look at Aspergillus: online monitoring via scattered light enables reproducible phenotyping.

ABSTRACT:

Background

Filamentously growing microorganisms offer unique advantages for biotechnological processes, such as extraordinary secretion capacities, going along with multiple obstacles due to their complex morphology. However, limited experimental throughput in bioprocess development still hampers taking advantage of their full potential. Miniaturization and automation are powerful tools to accelerate bioprocess development, but so far the application of such technologies has mainly been focused on non-filamentous systems. During cultivation, filamentous fungi can undergo remarkable morphological changes, creating challenging cultivation conditions. Depending on the process and product, only one specific state of morphology may be advantageous to achieve e.g. optimal productivity or

SUBMITTER: Jansen RP 

PROVIDER: S-EPMC6681481 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature