Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer.

ABSTRACT:

Background

Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive and lethal disease, lacking effective therapeutic approaches. Available therapies only marginally prolong patient survival and are frequently coupled with severe adverse events. It is therefore pivotal to investigate novel and safe pharmacological approaches. We have recently identified the ABC transporter, ABCC3, whose expression is dependent on mutation of TP53, as a novel target in PDAC. ABCC3-mediated regulation of PDAC cell proliferation and tumour growth in vivo was demonstrated and was shown to be conferred by upregulation of STAT3 signalling and regulation of apoptosis.

Methods

To verify the potential of ABCC3 as a pharmacological target, a small molecule inhibitor of ABCC3, referred to here as MCI-7

SUBMITTER: Adamska A 

PROVIDER: S-EPMC6681491 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature