Risk factors for persistent Aspergillus respiratory isolation in cystic fibrosis.

ABSTRACT:

Background

Aspergillus species are increasingly detected in the respiratory tracts of individuals with cystic fibrosis (CF), and chronic Aspergillus fumigatus is associated with more frequent hospitalizations for pulmonary exacerbations. However, patient and clinical factors that may contribute to the acquisition of persistent Aspergillus infection have yet to be identified. The objective of this study was to identify risk factors for development of Aspergillus respiratory isolation in CF.

Methods

A retrospective cohort study of participants in the CF Foundation Patient Registry between 2006 and 2012 was conducted. Generalized estimating equation models were used to evaluate the association between the development of persistent Aspergillus respiratory isolation and individua

SUBMITTER: Hong G 

PROVIDER: S-EPMC6681666 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature