Quantitative Imaging Biomarkers for ⁹⁰Y Distribution on Bremsstrahlung SPECT After Resin-Based Radioembolization.

ABSTRACT: Our purpose was to identify baseline imaging features in patients with liver cancer that correlate with ⁹⁰Y distribution on postprocedural SPECT and predict tumor response to transarterial radioembolization (TARE). Methods: This retrospective study was approved by the institutional review board and included 38 patients with hepatocellular carcinoma (HCC) (n = 23; 18/23 men; mean age, 62.39 ± 8.62 y; 34 dominant tumors) and non-HCC hepatic malignancies (n = 15; 9/15 men; mean age, 61.13 ± 11.51 y; 24 dominant tumors) who underwent 40 resin-based TARE treatments (August 2012 to January 2018). Multiphasic contrast-enhanced MRI or CT was obtained before and Bremsstrahlung SPECT within 2 h after TARE. Total tumor volume (cm³) and enhancing tumor volume

SUBMITTER: Schobert I 

PROVIDER: S-EPMC6681698 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature