Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson's disease.

ABSTRACT: Type-1 reactions (T1R) are pathological inflammatory episodes and main contributors to nerve damage in leprosy. Here, we evaluate the genewise enrichment of rare protein-altering variants in 7 genes where common variants were previously associated with T1R. We selected 474 Vietnamese leprosy patients of which 237 were T1R-affected and 237 were T1R-free matched controls. Genewise enrichment of nonsynonymous variants was tested with both kernel-based (sequence kernel association test [SKAT]) and burden methods. Of the 7 genes tested 2 showed statistical evidence of association with T1R. For the LRRK2 gene an enrichment of nonsynonymous variants was observed in T1R-free controls (P_SKAT-O = 1.6 × 10^-4). This genewise association was driven almost entirely by

SUBMITTER: Fava VM 

PROVIDER: S-EPMC6681704 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature