An immunometabolic pathomechanism for chronic obstructive pulmonary disease.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is an inflammatory condition associated with abnormal immune responses, leading to airflow obstruction. Lungs of COPD subjects show accumulation of proinflammatory T helper (Th) 1 and Th17 cells resembling that of autoreactive immune responses. As regulatory T (T_reg) cells play a central role in the control of autoimmune responses and their generation and function are controlled by the adipocytokine leptin, we herein investigated the association among systemic leptin overproduction, reduced engagement of glycolysis in T cells, and reduced peripheral frequency of T_reg cells in different COPD stages. These phenomena were also associated with an impaired capacity to generate inducible T_reg (iT_reg) cells f

SUBMITTER: Bruzzaniti S 

PROVIDER: S-EPMC6681742 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature