Relation of in-utero exposure to antiepileptic drugs to pregnancy duration and size at birth.

ABSTRACT:

Background

The associations of individual antiepileptic drugs (AEDs) with pregnancy duration and size at birth, and potential dose relations, are not well characterized.

Methods

This cohort study used nationwide Swedish register data (1996-2013). Adjusting for smoking, epilepsy and other AED indications, we used linear and quantile regression to explore associations with pregnancy duration, and birth weight, length, and head circumference (the last three operationalized as z-scores). We used logistic regression for preterm delivery, small for gestational age, and microcephaly. Lamotrigine was the reference drug.

Results

6,720 infants were exposed to AEDs in utero; AED exposure increased over the study period. Relative to lamotrigine-exposed infants, carbamazepine-expo

SUBMITTER: Margulis AV 

PROVIDER: S-EPMC6681941 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature