Amorphous TiO₂ Nanotubes as a Platform for Highly Selective Phosphopeptide Enrichment.

ABSTRACT: This work reports highly selective phosphopeptide enrichment using amorphous TiO₂ nanotubes (TiO₂NTs) and the same material decorated with superparamagnetic Fe₃O₄ nanoparticles (TiO₂NTs@Fe₃O₄NPs). TiO₂NTs and TiO₂NTs@Fe₃O₄NPs materials were applied for phosphopeptide enrichment both from a simple peptide mixture (tryptic digest of bovine serum albumin and α-casein) and from a complex peptide mixture (tryptic digest of Jurkat T cell lysate). The obtained enrichment efficiency and selectivity for phosphopeptides of TiO₂NTs and TiO₂NTs@Fe₃O₄NPs were increased to 28.7 and 25.3%, respectively, as compared to those of the well-establ

SUBMITTER: Kupcik R 

PROVIDER: S-EPMC6682070 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature