Proteomic analysis of meningiomas reveals clinically distinct molecular patterns.

ABSTRACT:

Background

Meningiomas represent one of the most common brain tumors and exhibit a clinically heterogeneous behavior, sometimes difficult to predict with classic histopathologic features. While emerging molecular profiling efforts have linked specific genomic drivers to distinct clinical patterns, the proteomic landscape of meningiomas remains largely unexplored.

Methods

We utilize liquid chromatography tandem mass spectrometry with an Orbitrap mass analyzer to quantify global protein abundances of a clinically well-annotated formalin-fixed paraffin embedded (FFPE) cohort (n = 61) of meningiomas spanning all World Health Organization (WHO) grades and various degrees of clinical aggressiveness.

Results

In total, we quantify 3042 unique proteins comparing patterns acros

SUBMITTER: Papaioannou MD 

PROVIDER: S-EPMC6682208 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature