Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii.

ABSTRACT: In 2016, the World Health Organization deemed antibiotic resistance one of the biggest threats to global health, food security, and development. The need for new methods to combat infections caused by antibiotic resistant pathogens will require a variety of approaches to identifying effective new therapeutic strategies. One approach is the identification of small molecule adjuvants that potentiate the activity of antibiotics of demonstrated utility, whose efficacy is abated by resistance, both acquired and intrinsic. To this end, we have identified compounds that enhance the efficacy of antibiotics normally ineffective against Gram-negative pathogens because of the outer membrane permeability barrier. We identified two adjuvant compounds that dramatically enhance sensitivity of Acinetob

SUBMITTER: Martin SE 

PROVIDER: S-EPMC6682313 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature