A single session of hyperbaric oxygen therapy demonstrates acute and long-lasting neuroplasticity effects in humans: a replicated, randomized controlled clinical trial.

ABSTRACT:

Purpose

Animal studies have demonstrated anti-inflammatory, and anti-nociceptive properties of hyperbaric oxygen therapy (HBOT). However, physiological data are scarce in humans. In a recent experimental study, the authors used the burn injury (BI) model observing a decrease in secondary hyperalgesia areas (SHA) in the HBOT-group compared to a control-group. Surprisingly, a long-lasting neuroplasticity effect mitigating the BI-induced SHA-response was seen in the HBOT-preconditioned group. The objective of the present study, therefore, was to confirm our previous findings using an examiner-blinded, block-randomized, controlled, crossover study design.

Patients and methods

Nineteen healthy subjects attended two BI-sessions with an inter-session interval of ≥28 days. The BIs w

SUBMITTER: Wahl AM 

PROVIDER: S-EPMC6682324 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature