Effectiveness of switching to very low nicotine content cigarettes plus nicotine patch versus reducing daily cigarette consumption plus nicotine patch to decrease dependence: an exploratory randomized trial.

ABSTRACT:

Background and aims

The United States Food and Drug Administration has proposed regulation to require that cigarettes contain very low nicotine content (VLNC). In contrast, reducing the number of cigarettes per day (CPD) is the most common current method to reduce nicotine. This trial aims to explore whether gradually transitioning to VLNC cigarettes plus nicotine patch or reducing CPD plus nicotine patch is more effective at decreasing nicotine dependence.

Design

A two-arm, individually randomized open-label trial.

Setting

Community setting, Vermont, USA.

Participants

Sixty-eight adult daily smokers (40% female) of ≥ 10 cigarettes/day who were not planning to quit in the next 30 days.

Interventions

All participants smoked study cigarettes with a nicotin

SUBMITTER: Klemperer EM 

PROVIDER: S-EPMC6682423 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature