Microvascular Disease, Peripheral Artery Disease, and Amputation.

ABSTRACT:

Background

The mechanism of adverse limb events associated with peripheral artery disease remains incompletely understood. We investigated whether microvascular disease is associated with amputation in a large cohort of veterans to determine whether microvascular disease diagnosed in any location increases the risk of amputation alone and in concert with peripheral artery disease.

Methods

Participants in the Veterans Aging Cohort Study were recruited from April 1, 2003 through December 31, 2014. We excluded participants with known prior lower limb amputation. Using time-updated Cox proportional hazards regression, we analyzed the effect of prevalent microvascular disease (retinopathy, neuropathy, and nephropathy) and peripheral artery disease status on the risk of incident a

SUBMITTER: Beckman JA 

PROVIDER: S-EPMC6682431 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature