A meta-analysis of the efficacy of gabapentin for treating alcohol use disorder.

ABSTRACT:

Background and aims

Studies of the efficacy of gabapentin for treating alcohol use disorder (AUD) have yielded mixed findings. The aims of our study were to estimate gabapentin's effects on six alcohol-related outcomes, test potential moderators, examine publication bias and evaluate the quality of the studies.

Methods

Meta-analysis of placebo-controlled randomized controlled trials (RCTs). Using PubMed and ClinicalTrials.gov, we selected RCTs of gabapentin's effects on alcohol consumption or a biochemical correlate of it, excluding studies limited to other primary outcomes or that combined gabapentin with other medications. We assessed study quality and used a random-effects model to analyze each outcome measure and the Egger regression test and funnel plots to assess publi

SUBMITTER: Kranzler HR 

PROVIDER: S-EPMC6682454 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature