Methods for comparing durability of immune responses between vaccine regimens in early-phase trials.

ABSTRACT: The ability to produce a long-lasting, or durable, immune response is a crucial characteristic of many highly effective vaccines. A goal of early-phase vaccine trials is often to compare the immune response durability of multiple tested vaccine regimens. One parameter for measuring immune response durability is the area under the mean post-peak log immune response profile. In this paper, we compare immune response durability across vaccine regimens within and between two phase I trials of DNA-primed HIV vaccine regimens, HVTN 094 and HVTN 096. We compare four estimators of this durability parameter and the resulting statistical inferences for comparing vaccine regimens. Two of these estimators use the trapezoid rule as an empirical approximation of the area under the marginal log response

SUBMITTER: Westling T 

PROVIDER: S-EPMC6682462 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature