Novel serum metabolites associate with cognition phenotypes among Bogalusa Heart Study participants.

ABSTRACT:

Background

Metabolomics study provides an opportunity to identify novel molecular determinants of altered cognitive function.

Methods

During 2013 to 2016 Bogalusa Heart Study (BHS) visit, 1,177 participants underwent untargeted, ultrahigh performance liquid chromatography-tandem mass spectroscopy metabolomics profiling. Global cognition and five cognition domains were also assessed. The cross-sectional associations of single metabolites with cognition were tested using multiple linear regression models. Weighted correlation network analysis was used to examine the covariable-adjusted correlations of modules of co-abundant metabolites with cognition. Analyses were conducted in the overall sample and according to both ethnicity and sex.

Results

Five known metabolites an

SUBMITTER: Shi M 

PROVIDER: S-EPMC6682535 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature