Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors.

ABSTRACT:

Background

Bodybuilding supplements can cause a profound cholestatic syndrome.

Aim

To describe the drug-Induced liver injury network's experience with liver injury due to bodybuilding supplements.

Methods

Liver injury pattern, severity and outcomes, potential genetic associations, and exposure to anabolic steroids by product analysis were analysed in prospectively enrolled subjects with bodybuilding supplement-induced liver injury with causality scores of probable or higher.

Results

Forty-four males (mean age 33 years) developed liver injury with a median latency of 73 days. Forty-one per cent presented with hepatocellular pattern of liver injury as defined by the R > 5 ([Fold elevation of ALT] ÷ [Fold elevation of Alk Phos] (mean, range = 6.4, 0.5-31.4, n = 42

SUBMITTER: Stolz A 

PROVIDER: S-EPMC6682544 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature