Binding mechanisms of half-sandwich Rh(III) and Ru(II) arene complexes on human serum albumin: a comparative study.

ABSTRACT: Various half-sandwich ruthenium(II) arene complexes and rhodium(III) arene complexes have been intensively investigated due to their prominent anticancer activity. The interaction of the organometallic complexes of Ru(η⁶-p-cymene) and Rh(η⁵-C₅Me₅) with human serum albumin (HSA) was studied in detail by a combination of various methods such as ultrafiltration, capillary electrophoresis, ¹H NMR spectroscopy, fluorometry and UV-visible spectrophotometry in the presence of 100 mM chloride ions. Binding characteristics of the organometallic ions and their complexes with deferiprone, 2-picolinic acid, maltol, 6-methyl-2-picolinic acid and 2-quinaldic acid were evaluated. Kinetic aspects and reversibility of the albumin binding are also discu

SUBMITTER: Domotor O 

PROVIDER: S-EPMC6682546 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature