The Disease-Free Interval Between Resection of Primary Colorectal Malignancy and the Detection of Hepatic Metastases Predicts Disease Recurrence But Not Overall Survival.

ABSTRACT:

Introduction

The disease-free interval (DFI) between resection of primary colorectal cancer (CRC) and diagnosis of liver metastases is considered an important prognostic indicator; however, recent analyses in metastatic CRC found limited evidence to support this notion.

Objective

The current study aims to determine the prognostic value of the DFI in patients with resectable colorectal liver metastases (CRLM).

Methods

Patients undergoing first surgical treatment of CRLM at three academic centers in The Netherlands were eligible for inclusion. The DFI was defined as the time between resection of CRC and detection of CRLM. Baseline characteristics and Kaplan-Meier survival estimates were stratified by DFI. Cox regression analyses were performed for overall (OS) and disea

SUBMITTER: Hoppener DJ 

PROVIDER: S-EPMC6682566 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature