Aspects of vincristine-induced neuropathy in hematologic malignancies: a systematic review.

ABSTRACT:

Purpose

Vincristine is widely used as anticancer therapy for a variety of hematological malignancies. The treatment is limited by progressive vincristine-induced neuropathy, possibly including both peripheral sensory and motor nerves, autonomic nervous functions, and the central nervous system. This dose-limiting side-effect can diminish quality of life and, furthermore, cause discontinuation of vincristine treatment. The present review elucidates the current knowledge regarding vincristine-induced neuropathy in hematologic malignancies, focusing on neuropathy assessment, clinical and molecular predictive markers, drug-drug interference, prevention, and treatment.

Methods

This review is conducted by a systematic search strategy for the identification of relevant literature i

SUBMITTER: Madsen ML 

PROVIDER: S-EPMC6682573 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature