Comparison between dynamic gadoxetate-enhanced MRI and ^99mTc-mebrofenin hepatobiliary scintigraphy with SPECT for quantitative assessment of liver function.

ABSTRACT:

Objectives

To compare Gd-EOB-DTPA dynamic hepatocyte-specific contrast-enhanced MRI (DHCE-MRI) with ^99mTc-mebrofenin hepatobiliary scintigraphy (HBS) as quantitative liver function tests for the preoperative assessment of patients undergoing liver resection.

Methods

Patients undergoing liver surgery and preoperative assessment of future remnant liver (FRL) function using ^99mTc-mebrofenin HBS were included. Patients underwent DHCE-MRI. Total liver uptake function was calculated for both modalities: mebrofenin uptake rate (MUR) and Ki respectively. The FRL was delineated with both SPECT-CT and MRI to calculate the functional share. Blood samples were taken to assess biochemical liver parameters.

Results

A total of 20 patients were included. The HBS

SUBMITTER: Rassam F 

PROVIDER: S-EPMC6682576 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature