Mouse CD8⁺NKT-like cells exert dual cytotoxicity against mouse tumor cells and myeloid-derived suppressor cells.

ABSTRACT: Our previous work has demonstrated the high efficiency of CD8⁺ natural killer T (NKT)-like cells in killing antigen-bearing dendritic cells. To evaluate their role in the tumor microenvironment, we performed in vitro and in vivo antitumor experiments to investigate whether CD8⁺NKT-like cells could kill Yac-1 and B16 cells like NK cells and kill EL4-OVA8 cells in an antigen-specific manner like cytotoxic T lymphocytes (CTLs). Unlike NK1.1^-CTLs, CD8⁺NKT-like cells also exhibit the capability to kill myeloid-derived suppressor cells (MDSCs) in an antigen-specific manner, indicative of their potential role in clearing tumor antigen-bearing MDSCs to improve the antitumor microenvironment. In vitro blocking experiments showed that granzyme B inhibitor

SUBMITTER: Li Z 

PROVIDER: S-EPMC6682577 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature