Moving Myeloid Leukemia Drug Discovery Into the Third Dimension.

ABSTRACT: The development of therapies aimed at leukemia has progressed substantially in the past years but childhood acute myeloid leukemia (AML) remains one of the most challenging cancers to treat. Genomic profiling of AML has greatly enhanced our understanding of the genetic and epigenetic landscape of this high-risk leukemia. With it comes the opportunity to develop targeted therapies that are expected to be more effective and less toxic than current treatment regimens. Nevertheless, often overlooked in leukemia drug discovery are the dynamic interactions between leukemic cells and the bone marrow environment. The interplay between leukemic cells, stromal cells and the extracellular matrix plays critical roles in the development, progression and relapse of AML as well as in drug response and th

SUBMITTER: Cartledge Wolf DM 

PROVIDER: S-EPMC6682595 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature