Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP_swe/PS1_ΔE9 Transgenic Mice.

ABSTRACT: Insulin-like growth factor-1 (IGF-1) is a pleiotropic molecule with neurotrophic and immunomodulatory functions. Knowing the capacity of chronically activated microglia to produce IGF-1 may therefore show essential to promote beneficial microglial functions in Alzheimer's disease (AD). Here, we investigated the expression of IGF-1 mRNA and IGF-1 along with the expression of tumor necrosis factor (TNF) mRNA, and the amyloid-β (Aβ) plaque load in the hippocampus of 3- to 24-month-old APP_swe/PS1_ΔE9 transgenic (Tg) and wild-type (WT) mice. As IGF-1, in particular, is implicated in neurogenesis we also monitored the proliferation of cells in the subgranular zone (sgz) of the dentate gyrus. We found that the Aβ plaque load reached its maximum in aged 21- and 24-month-old AP

SUBMITTER: Myhre CL 

PROVIDER: S-EPMC6682662 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature