Monocyte recruitment and activated inflammation are associated with thyroid carcinogenesis in a mouse model.

ABSTRACT: Thyroid cancer is the most common endocrine malignancy. Although an association between inflammation and thyroid cancer has long been recognized, a cause-effect relationship at the molecular level has yet to be elucidated. We explored how inflammation could contribute to thyroid carcinogenesis in Thrb^PV/PVPten^+/- mice. The Thrb^PV/PVPten^+/- mouse expresses a dominantly negative thyroid hormone receptor β (denoted as PV) and a deletion of one single allele of the Pten gene. This mutant mouse exhibits aggressive follicular thyroid cancer similarly as in patients. We found significantly increased infiltration of inflammatory monocytes in thyroid tumors of Thrb^PV/PVPten^+/- mice, while no apparent changes in m

SUBMITTER: Park S 

PROVIDER: S-EPMC6682719 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature