High versus low positive end-expiratory pressure during general anaesthesia for open abdominal surgery (PROVHILO trial): a multicentre randomised controlled trial.

ABSTRACT:

Background

The role of positive end-expiratory pressure in mechanical ventilation during general anaesthesia for surgery remains uncertain. Levels of pressure higher than 0 cm H2O might protect against postoperative pulmonary complications but could also cause intraoperative circulatory depression and lung injury from overdistension. We tested the hypothesis that a high level of positive end-expiratory pressure with recruitment manoeuvres protects against postoperative pulmonary complications in patients at risk of complications who are receiving mechanical ventilation with low tidal volumes during general anaesthesia for open abdominal surgery.

Methods

In this randomised controlled trial at 30 centres in Europe and North and South America, we recruited 900 patients at risk

SUBMITTER: PROVE Network Investigators for the Clinical Trial Network of the European Society of Anaesthesiology 

PROVIDER: S-EPMC6682759 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature