Chronic equine hepacivirus infection in an adult gelding with severe hepatopathy.

ABSTRACT: BACKGROUND:Equine hepacivirus (EqHV) in equids represents the closest homologue to hepatitis C virus (HCV) infecting humans. A majority of HCV infected patients develop a chronic course of infection leading to liver fibrosis, cirrhosis and liver failure. However, in horses mostly transient mild subclinical infections are reported for EqHV to date. OBJECTIVES:EqHV can be involved in chronic liver diseases of horses. METHODS:Biochemical parameters in serum samples were measured. Viral load was determined using qPCR. Next generation sequencing (NGS) of serum was performed. Liver tissue was stained with haematoxylin and eosin and analysed for viral RNA with fluorescent in situ-hybridization. RESULTS:The horse showed symptoms of severe hepatopathy and was chronically infected with EqHV. Viral R

SUBMITTER: Tegtmeyer B 

PROVIDER: S-EPMC6682795 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature