Concordant expression pattern across multiple immune tissues of commercial broilers in response to avian pathogenic Escherichia coli (APEC).

ABSTRACT: In this study, RNA-seq gene expression data were obtained for three different immune tissues (bone marrow, thymus, and bursa) at two time points from birds with three phenotypes (non-infected, resistant, and susceptible birds). A total of 380 significant differentially expressed genes (DEGs) were commonly expressed in each of the three tissues in the contrast of susceptible vs. non-infected birds at 5 days post-infection (dpi) and 106 significant DEGs were shared in susceptible vs. resistant birds at 5 dpi. For the co-expressed DEGs, a relatively high consistency in expression pattern was identified in the three tissues for the two contrasts. These co-expressed DEGs were involved in the biological process of response to stimulus, regulation of cell proliferation, signal transduction, and i

SUBMITTER: Sun H 

PROVIDER: S-EPMC6682839 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature