Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA.

ABSTRACT: The increasing antibiotic resistance evolved by Helicobacter pylori has alarmingly reduced the eradication rates of first-line therapies. To overcome the current circulating resistome, we selected a novel potential therapeutic target in order to identify new candidate drugs for treating H. pylori infection. We screened 1120 FDA-approved drugs for molecules that bind to the essential response regulator HsrA and potentially inhibit its biological function. Seven natural flavonoids were identified as HsrA binders. All of these compounds noticeably inhibited the in vitro DNA binding activity of HsrA, but only four of them, apigenin, chrysin, kaempferol and hesperetin, exhibited high bactericidal activities against H. pylori. Chrysin showed the most potent bactericidal activity and the most syn

SUBMITTER: Gonzalez A 

PROVIDER: S-EPMC6683298 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature