Association of Constipation with risk of end-stage renal disease in patients with chronic kidney disease.

ABSTRACT:

Background

Chronic Kidney Disease (CKD) is a growing public health problem. Many risk factors were identified and interventions were applied accordingly, but the incidence of end-stage renal disease continued increasing. Some other risk factors may be ignored. Gut microbiota has been recognized as an important endogenous organ. The kidney-gut axis would contribute to gut dysbiosis, which might worsen CKD. Constipation, commonly seen in CKD, was one of the clinical presentation of gut dysbiosis. The clinical impact of constipation to CKD remains unknown. Our study aimed at assessing the risk of ESRD between CKD patients with and without constipation in a nationwide database.

Methods

We identified newly diagnosed cases of CKD without constipation history before in 2000-2011 fr

SUBMITTER: Lu CY 

PROVIDER: S-EPMC6683335 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature