Deoxysphingolipids and ether-linked diacylglycerols accumulate in the tissues of aged mice.

ABSTRACT:

Background

Senescence is a well-known risk factor for several diseases, such as neurodegenerative disorders. Therefore, studies exploring the mechanisms underlying aging are expected to guide the discovery of novel drug targets and biomarkers for these diseases. However, a comprehensive overview of the metabolic and lipidomic changes in healthy aging mammals is lacking. To understand the changes of metabolism with aging, especially lipid metabolism, we analyzed the metabolomes and lipidomes of the cerebral cortex, liver, femoral muscle, and epididymal fat in young and aged mice.

Results

Two-dimensional cluster analysis revealed clear separation between the metabolite profiles of the aged and young groups. Deoxydihydroceramide (doxDHCer), deoxyceramide (doxCer), and ether-lin

SUBMITTER: Ando A 

PROVIDER: S-EPMC6683348 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature