Emergency Etoposide-Cisplatin (Em-EP) for patients with germ cell tumours (GCT) and trophoblastic neoplasia (TN).

ABSTRACT:

Background

Etoposide (E) at 100 mg/m² combined with Cisplatin (P) at 20 mg/m² represents an induction 2-day regimen embedded in our clinical practice for patients with advanced GCT or TN at high risk of early death. We evaluated 24/7 Em-EP administration to a combined GCT-TN cohort at our Emergency Cancer Treatment Centre (ECTC) to determine its efficacy within the acute setting.

Methods

Patients who received Em-EP during a five-year interval were identified from electronic databases at Imperial College Healthcare NHS Trust. Data collected included demographics, treatment details and clinical outcome.

Results

Em-EP was administered in the emergency setting to 104 patients, predominantly young adults (median age 35, range 17-71). Half the cases we

SUBMITTER: Chan Wah Hak C 

PROVIDER: S-EPMC6683367 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature