Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8⁺ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes.

ABSTRACT:

Background

Adoptive T cell-transfer (ATC) therapy is a highly promising cancer-treatment approach. However, in vivo-administered T cells tend to disperse, with only a small proportion reaching the tumour. To remedy this, magnetic targeting of T cells has been recently explored. Magnetic nanoparticles (MNPs) functionalised with antibodies were attached to effector T cells and magnetically recruited to tumour sites under MRI guidance. In this study, we investigated whether 3-aminopropyl-triethoxysilane (APS)-coated MNPs directly attached to CD8⁺ T cell membranes could also magnetically target and accumulate tumour-specific CD8⁺ T cells in solid tumours using an external magnetic field (EMF). As it has been shown that T cells associated with APS-coated MNPs are r

SUBMITTER: Sanz-Ortega L 

PROVIDER: S-EPMC6683429 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature