Programmable multi-DNA release from multilayered polyelectrolytes using gigahertz nano-electromechanical resonator.

ABSTRACT:

Background

Controllable and multiple DNA release is critical in modern gene-based therapies. Current approaches require complex assistant molecules for combined release. To overcome the restrictions on the materials and environment, a novel and versatile DNA release method using a nano-electromechanical (NEMS) hypersonic resonator of gigahertz (GHz) frequency is developed.

Results

The micro-vortexes excited by ultra-high frequency acoustic wave can generate tunable shear stress at solid-liquid interface, thereby disrupting molecular interactions in immobilized multilayered polyelectrolyte thin films and releasing embedded DNA strands in a controlled fashion. Both finite element model analysis and experiment results verify the feasibility of this method. The release rate and

SUBMITTER: Guo X 

PROVIDER: S-EPMC6683436 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature