Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese.

ABSTRACT:

Background

The spectrum of classical and non-classical HLA genes related to the risk of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) in the Japanese population has not been studied in detail. We conducted a case-control analysis of classical and non-classical HLA genes.

Methods

We used next-generation sequencing (NGS)-based HLA genotyping methods for mapping risk for 45 MS patients, 31 NMOSD patients, and 429 healthy controls. We evaluated the association of the HLA variants with the risk of MS and NMOSD using logistic regression analysis and Fisher's exact test.

Results

We confirmed that HLA-DRB1*15:01 showed the strongest association with MS (P = 2.1 × 10^-5; odds ratio [OR] = 3.44, 95% confidence interval [95% CI] = 1.95-6.07

SUBMITTER: Ogawa K 

PROVIDER: S-EPMC6683481 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature