Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats.

ABSTRACT:

Background

MDMA causes serotonin (5-HT) syndrome immediately after administration and serotonergic injury in a few days or weeks. However, a serotonin syndrome is not always followed by serotonergic injury, indicating different mechanisms responsible for two adverse effects. The goal of present study was to determine causes for two adverse events and further test that dose and environment have a differential role in initiating and intensifying MDMA neurotoxicity.

Methods

Initiation and intensification were examined by comparing neurotoxic effects of a high-dose (10 mg/kg × 3 at 2 h intervals) with a low-dose (2 mg/kg × 3) under controlled-environmental conditions. Initiation of a serotonin syndrome was estimated by measuring extracellular 5-HT, body-core temperature, electro

SUBMITTER: Shokry IM 

PROVIDER: S-EPMC6683525 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature