GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway.

ABSTRACT:

Background

The GKN2 is a secretory protein, whose levels decrease in gastric cancer. The present study aimed to investigate the expression, function and mechanism of action of GKN2 in gastric cancer.

Methods

Molecular biology assays were performed to elucidate the function and underlying mechanisms of GKN2 in gastric cancer under stress-induced condition in vivo and in vitro. Clinical specimens were used to assess the correlation of GKN2 and prognosis.

Results

We found that overexpression of GKN2 significantly enhanced apoptosis and growth arrest in vitro. GKN2 expression increased in gastric cancer cells exposed to hydrogen peroxide and promoted reactive oxygen species-induced mitochondrial dysfunction and resulted in increased cell apoptosis via inhibition of NF-κB

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6683576 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature