EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) is a common, complex, and highly heritable inflammatory skin disease. Genome-wide association studies offer opportunities to identify molecular targets for drug development. A risk locus on chromosome 11q13.5 lies between 2 candidate genes, EMSY and LRRC32 (leucine-rich repeat-containing 32) but the functional mechanisms affecting risk of AD remain unclear.

Objectives

We sought to apply a combination of genomic and molecular analytic techniques to investigate which genes are responsible for genetic risk at this locus and to define mechanisms contributing to atopic skin disease.

Methods

We used interrogation of available genomic and chromosome conformation data in keratinocytes, small interfering RNA (siRNA)-mediated knockdown in skin

SUBMITTER: Elias MS 

PROVIDER: S-EPMC6683598 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature