Composition of the mucosa-associated microbiota along the entire gastrointestinal tract of human individuals.

ABSTRACT:

Background

Homeostasis of the gastrointestinal tract depends on a healthy bacterial microbiota, with alterations in microbiota composition suggested to contribute to diseases. To unravel bacterial contribution to disease pathology, a thorough understanding of the microbiota of the complete gastrointestinal tract is essential. To date, most microbial analyses have either focused on faecal samples, or on the microbial constitution of one gastrointestinal location instead of different locations within one individual.

Objective

We aimed to analyse the mucosal microbiome along the entire gastrointestinal tract within the same individuals.

Methods

Mucosal biopsies were taken from nine different sites in 14 individuals undergoing antegrade and subsequent retrograde double-ba

SUBMITTER: Vuik F 

PROVIDER: S-EPMC6683645 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature