Glomerular Volume and Glomerulosclerosis at Different Depths within the Human Kidney.

ABSTRACT:

Background

Age, CKD risk factors, and kidney function are associated with larger glomerular volume and a higher percentage of globally sclerotic glomeruli. Knowledge of how these associations may differ by cortical depth is limited.

Methods

To investigate glomerular volume and glomerulosclerosis across different depths of cortex, we studied wedge sections of the renal parenchyma from 812 patients who underwent a radical nephrectomy (for a tumor), separately characterizing glomeruli in the superficial (subcapsular), middle, and deep (juxtamedullary) regions. We compared the association of mean nonsclerotic glomerular volume and of glomerulosclerosis (measured as the percentage of globally sclerotic glomeruli) with age, obesity, diabetes, smoking, kidney function, and structur

SUBMITTER: Denic A 

PROVIDER: S-EPMC6683701 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature