A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection.

ABSTRACT:

Background

In kidney transplant recipients, surveillance biopsies can reveal, despite stable graft function, histologic features of acute rejection and borderline changes that are associated with undesirable graft outcomes. Noninvasive biomarkers of subclinical acute rejection are needed to avoid the risks and costs associated with repeated biopsies.

Methods

We examined subclinical histologic and functional changes in kidney transplant recipients from the prospective Genomics of Chronic Allograft Rejection (GoCAR) study who underwent surveillance biopsies over 2 years, identifying those with subclinical or borderline acute cellular rejection (ACR) at 3 months (ACR-3) post-transplant. We performed RNA sequencing on whole blood collected from 88 individuals at the time of 3-mo

SUBMITTER: Zhang W 

PROVIDER: S-EPMC6683710 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature